The last decade has seen a steady growth in comprehensive tumor profiling as NGS has enabled the transition from hot-spot assays to large 100+ gene panels. As the list of potential driver genes has grown, so has the size of the panels, with exome panels becoming more common in recent years. Yet, targeted sequencing significantly complicates the sample prep workflow, and even exomes have proven insufficient as they can miss important drivers such as promoter mutations or structural variants.

With the UG 100™, deep whole genome profiling is an economically feasible option for comprehensive profiling with significant advantages:

• Simple, cost effective workflow
• Stable, lasting assay
• Enhanced ability to detect structural and copy number variation