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Methylation Sequencing on the UG 100™

Epigenetic modifications, like DNA methylation, play a key role in gene expression regulation and other important cellular processes. Unfortunately many studies to date have had to make a trade-off between sequencing more samples or sequencing more of the genome.

The UG 100™ provides an economical way to do both, with large scale genome-wide methylation studies at scale.

  • Detect tens of millions of CpG sites per sample with accuracy comparable to legacy approaches
  • Compatibility with standard analysis tools
  • Genome-wide methylation profiling from cfDNA
  • Compatibility with multiple sample prep methods, including EM-seq and bisulfite conversion
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Resources

Publications

Read how our collaborator Mike Snyder is using methylation sequencing to reveal trajectories in precancerous polyps to early colorectal adenocarcinoma.

Read Publication

Application Note

Learn how to perform genome wide DNA methylation profiling using the UG 100™

Read App Note

Data

Check out our whole genome methylation standard reference GIAB dataset.

Download Dataset

Poster

Learn how high-depth colorectal cancer whole genome methylation sequencing can reveal trajectories in disease progression.

Read Poster

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