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MRD and Rare Event Detection

The pursuit of rare variant detection takes on a role of paramount importance, particularly when examining Minimal Residual Disease (MRD) aiming to comprehend and monitor diseases at their most minuscule levels. Identifying these variants at extremely low allelic fraction not only informs clinicians about the efficacy of therapies but also serves as an early warning system, signaling the potential for disease recurrence.

The impact of rare variant detection extends beyond cancer. Recent studies have shown that even many tissues are actually composed of multiple genetically distinct cell populations. Being able to identify these often tiny clones might hold a key to understanding and potentially mitigating numerous diseases.

A future where the early detection of rare variants becomes routine has the potential to transform the paradigm of patient care. This journey into the depths of rare variant detection is not merely a scientific pursuit; it's a beacon of hope, holding the promise of more precise, personalized, and effective healthcare for those navigating the complexities of MRD and beyond.

The UG 100™ facilitates sensitive detection of rate variants using:

  • High percentage of reported variants with BQ60 or greater
  • Built-in error correction of sample/sample prep induced artifacts (ppmSeq)
  • Affordable deep WGS unlocking unprecedented limit of detection levels
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Read our NYGC collaborator Dan Landau's pre-print utilizing whole genome error corrected sequencing for sensitive ct DNA cancer monitoring.

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Application Notes

Discover the power of our ppmSeq™ and Q60 SNV accuracy for MRD and rare event detection.

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Learn how we utilize the IDT xGen™ cfDNA & FFPE Library Prep Kit to perform WGS to generate and detect MRD signatures.

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