Mostly natural sequencing-by-synthesis for scRNA-seq using Ultima sequencing

In this Nature Biotechnology publication from Simmons, S. et al (Klarman Cell Observatory & Ultima Genomics), the authors introduce a mostly natural sequencing-by-synthesis (mnSBS) method for single-cell RNA sequencing (scRNA-seq), adapted to the Ultima genomics platform, and systematically benchmark it against current scRNA-seq technology, demonstrating successful application in four scRNA-seq case studies of different technical and biological types.